A protein that is necessary for the formation of the vertebrate brain has been identified by researchers at the Harvard Stem Cell Institute (HSCI) and Boston Children’s Hospital, in collaboration with scientists from Oxford and Rio de Janeiro.The researchers say the finding, which has been successfully demonstrated in frog embryos, will help scientists control differentiation of various cell types.Their study was given early online Thursday and is being published in print in the March 23 issue of the journal Developmental Cell. Xinjun Zhang and Seong-Moon Cheong, both postdoctoral fellows in the laboratory of HSCI-affiliated faculty member Xi He at Boston Children’s Hospital, are co-first authors.The protein, Notum, first discovered in fruit flies in 2002 and then found in mice and humans, is one of many that help determine embryonic development. For some time, researchers have known that Notum regulates wing formation in flies. But until recently, it was not known how Notum affected vertebrate embryo development. In collaboration with researchers from University of Oxford and Federal University of Rio de Janeiro, He and colleagues compared how frog embryos — which are considered models for human embryos — developed with and without Notum.When the researchers injected frog embryos with Notum, the embryos grew bigger brains and heads. When Notum was not present, the embryos would become a sack of skin cells with no head and a tiny brain, a result of embryonic progenitor cells making only epidermal but not neural cells.Simply put, said He, “The frog brain cannot be properly formed without Notum.”These findings could benefit stem cell researchers trying to create specific tissue types or organs in the lab. In order to guide or direct stem cells to differentiate into a given cell type, such as neural cells or muscle cells, researchers continue to alter their experimental recipes, fine-tuning which molecules should be added to their dishes in what sequence and amount.For those trying to create neural cells, “Notum is a necessary ingredient and new tool in the kit box for researchers to instruct human progenitor cells to become neural tissues,” said He, who is also an American Cancer Society research professor.Additionally, the researchers were able to demonstrate how Notum deactivates Wnt, which is a family of proteins that direct stem cells to “self-renew,” or make more stem cells, among other things. If left unchecked, Wnt could cause certain types of cancer, such as gastrointestinal, brain, and blood cancers.The study builds on previous work by HSCI Co-Director Doug Melton, who early in his career did groundbreaking research on the development of the frog nervous system.Its findings complement related research published by Satoshi Kakugawa, Paul F. Langton, and Matthias Zebisch and colleagues in Nature.
As stated in the explanation of the Decision, the skill of performing it is still transmitted orally. Osim njega, mogu se susresti i nazivi taraban, drmeš, samo šokačko ili samo kolo. “Danas je uvriježen naziv šokačko kolo koji ovaj ples na kružnici jasno razlikuje od plesova istog tipa. Sva ostala kola, plesovi na kružnici, nazivaju se najčešće po prvom stihu pjesme uz koju se izvode poput ‘ajd na livo, Jaši baba dorata i dr., dok je za ovaj ples dovoljno reći kolo i svima je jasno o čemu se radi. S obzirom na povezanost tog plesa s Hrvatima Šokcima, koji žive u Hrvatskoj i izvan nje, najpogodniji naziv je upravo šokačko kolo jer se njime referira na cijelo područje na kojemu žive Hrvati Šokci. U granicama Republike Hrvatske to je područje Slavonije, Baranje i Srijema”,, napominje pomoćnik ministrice kulture Davor Trupković. To the Šokci Croats from the area of Slavonia, Baranja and Srijem, the favorite traditional dance, ie the Šokac kolo, was granted the status of an intangible cultural asset by the December Decision of the Ministry of Culture, Directorate for the Protection of Cultural Heritage . The process of creating new popcorn is no longer so lively, so you can hear mostly their older variants in the shock circle. U prošlosti se izvodilo uz tradicijske instrumente poput gajdi ili tambure samice, da bi se tijekom 20. stoljeća razvila praksa izvođenja uz pratnju tamburaškog sastava. Kao društveno događanje šokačko kolo je do sredine 20. stoljeća bilo važno za život zajednice, okupljalo se za seoske svečanosti te o pokladama, a neizostavni dio bilo je upravo plesanje šokačkog kola, u užem smislu značenja. Naziv šokačko kolo uvriježio se tijekom 20. stoljeća uslijed scenske primjene te je i danas na terenu poznat pojam ne samo među Hrvatima Šokcima, nego je znatno rasprostranjeniji, opće prihvaćen. Photo: Vinkovci Autumns He adds that ZAKUD plans to organize seminars, workshops and similar educational programs, where interested participants could learn all about the Šokac circuit, but also other original dances of Vinkovci and the surrounding area. The holders of the property are the Association of Cultural and Artistic Activities of the Vukovar-Srijem County, the Association of KUDs of the Đakovo Region and the Brod Folklore Ensemble, writes the Novosti.hr portal. He also notes that the ten-line verses of the Šokac Circle have today been almost equated with the Bečar, so you can often hear texts that follow current social events. Source: Novosti.hr Spontaneous performances involve dancing, ie playing the shock wheel in various ceremonies such as weddings, religious ceremonies or informal gatherings when the wheel is performed to mark a special moment in a social event. The biggest shock wheel in the world? Photo: Vinkovci Autumns, Darko Puharić In this way, their long-term initiative to declare the Šokac circuit an intangible cultural asset was crowned. In this case, it was not possible to specify only one settlement to which the intangible cultural property would be connected, but to go to several of them, and by definition, the Šokačko kolo is a traditional dance performed with song and instrumental accompaniment. “In the last ten years, maybe even longer, we have been working intensively on preserving the originality of our traditional dances and customs, and this is certainly a big step towards that. It is invaluable to leave a legacy to the younger generations, something specifically documented and preserved, because in this way we preserve these dances, but also the songs and tunes of this area. This is a confirmation that the shock wheel is something that is good and of good quality and that needed to be protected. My great wish is that we now transfer this dance to schools, that is, that children in primary schools, through, say, folklore, learn about the traditional dances of their region. Of course, we teach children such things in cultural and artistic societies, but I think that this education should be expanded, and this status of the shock circle is proof of that.”, Points out the head of the State Festival of Original Croatian Folklore Danijel Šota, for Novosti.hr.
The NBA season will not resume for at least 30 days, commissioner Adam Silver said Thursday.Jazz stars Rudy Gobert and Donovan Mitchell have tested positive for coronavirus, and the NBA announced on Wednesday it was suspending its season. “We don’t know enough to be more specific than that, but we wanted to give direction to our players and teams and to our fans that this is going to be roughly at least a month.”NBA Commissioner Adam Silver discusses the timetable for the league’s suspension. pic.twitter.com/tterVvR29r— NBA on TNT (@NBAonTNT) March 13, 2020Silver said there was a possibility the rest of the NBA campaign and the playoffs would be canceled.”Of course it’s possible,” he said in response to a question by TNT’s Ernie Johnson. “I just don’t know more at this point.” MORE: Charles Barkley takes coronavirus test, self-quarantinesSilver said the suspension would last at least a month because of the coronavirus, or COVID-19, which has killed 4,983 people around the world.”What we determined today is that this hiatus will be most likely at least 30 days,” he told TNT.
Takeru Kobayashi is done hot doggin’ it.The Japanese competitive eater dominated the Nathan’s Hot Dog Eating Contest in the early 2000s. His reign launched the event’s popularity into an entirely new stratosphere, but soon after his six straight title wins, Kobayashi was nowhere to be found. Kobayashi hot dog eating contest resultsKobayashi was doing things with his mouth and stomach that were previously unseen in the hot dog eating contest.He burst onto the scene in 2001, devouring 50 dogs; second-place winner Arai Saitama ate 31. Both competitors broke the previous record, but Kobayashi took home the glory.In 2011, Kobayashi once again set a world record with 69 nice hot dogs consumed, “beating out” Chestnut by one dog. The catch: Kobayashi set the mark at a rooftop bar, not at the Nathan’s event, which he was banned from. Kobayashi’s record was officiated by two ordained judges, so it was legitimate. The record would eventually be broken by Chestnut.YearHot dogs eatenPlace200150First200250First200344 1/2First200453 1/2First200549First200653 3/4First200763Second200859Second200964 1/2Second Kobayashi dazzled — and grossed out — the masses with his ability to shove dog after dog straight down the gullet, with his signature shimmy and his diminutive stature. Once Joey Chestnut arrived on the scene to challenge Kobayashi, Chestnut dethroned the champ and started a dynasty of his own.Since then, Kobayashi has strayed further and further from the frankfurter.So, what happened to “Kobi?” MORE: Nathan’s Hot Dog Eating Contest prop bets — does ‘Jaws’ have another win in his stomach?What happened to Kobayashi?The answer is … not much.If you’re expecting the tragic downfall of a once-dominant champion, there’s not really much there. There is lots of red tape, though.While Joey “Jaws” Chestnut’s arrival subsequently ended Kobayashi’s reign of six consecutive hot dog eating titles, it wasn’t until 2010 when Kobayashi’s eating career started to spiral. Kobayashi entered a contract dispute with Major League Eating, which sanctions the Nathan’s Hot Dog Eating Contest, leading to the end of his appearances on Coney Island during the Fourth of July spectacle.His disputes with MLE prevented Kobayashi from competing at events outside of the MLE banner, resulting in Kobayashi’s ban from the Nathan’s Hot Dog Eating Contest in subsequent years, effectively ending his chance at redemption vs. Chestnut.In 2010, Kobayashi infamously rushed the stage at the Nathan’s Hot Dog Eating Contest, resulting in his arrest. While there are conflicting reports as to what exactly happened, Kobayashi maintains that he took the stage to appease fans at the event who were chanting his name and congratulate Chestnut for his victory. The 2009 competition would be the last that Kobayashi would be involved in.In 2011, from a rooftop bar and set during the same time as the traditional hot dog eating contest, Kobayashi downed 69 hot dogs setting a world record, thus “challenging” Chestnut for hot dog supremacy. Even with the officials, though, it wasn’t quite as sweet as raising the mustard belt at the corner of Surf and Stillwell.In recent years, Kobayashi has still been chomping away, just in relative obscurity, away from the spotlight of the Fourth of July. In 2019, he was one of the subjects of the ESPN 30-for-30 documentary “The Good, The Bad, The Hungry” alongside Chestnut, which detailed the chompers’ rivalry.